In vitro studies show H. erinaceus exhibits antioxidant and anti-inflammatory properties that may protect neurons from oxidative stress and inflammation.[4]
Compounds in H. erinaceus like erinacines and hericenones have demonstrated neuroprotective effects against Alzheimer's disease pathology in animal models.[3]
Animal research suggests H. erinaceus may help regulate blood sugar levels, which could be beneficial for diabetes management.[5]
While promising, most human studies on H. erinaceus have been small pilot trials. Larger clinical trials are needed to confirm these potential benefits and establish optimal dosages.[1][3]
Dosages ranging from 500mg to 5000mg per day, taken in divided doses, have shown benefits in some studies.[3][4]
While Lion's Mane is generally considered safe, even at higher doses, it's advisable to start with lower dosages (250-750mg per day) and gradually increase as needed. Consulting a healthcare professional, especially if taking medications or having underlying conditions, is recommended to determine the appropriate dosage.[2]
Some individuals with mushroom allergies may experience allergic reactions like skin rashes, breathing difficulties, or throat swelling when taking Lion's Mane supplements.[1][3] If you have a known mushroom allergy, it's advisable to avoid Lion's Mane or consult a doctor before use.
In one clinical study, mild side effects like abdominal discomfort and diarrhea were reported with Lion's Mane supplementation.[4]
Overall, Lion's Mane mushroom is considered relatively safe for most people when taken at recommended doses. However, those with mushroom allergies, taking certain medications, or having specific medical conditions should exercise caution and consult their doctor before supplementing with Lion's Mane[1][3][4].